During administration of losartan, removal of the angiotensin II negative feedback on renin secretion leads to increased plasma renin activity (PRA). Cozaar; Descriptions. Losartan dosing information. The rates of cardiovascular death and myocardial infarction were not significantly different between the treatment groups. VA NEPHRON-D was a study in patients with type 2 diabetes mellitus and diabetic nephropathy. What are the differences between losartan and other medicines for high blood pressure? For more information about how losartan can affect you and your baby during pregnancy, visit the Best Use of Medicines in Pregnancy (BUMPS) website. No, there's no evidence that losartan is addictive. Continue typing to refine. In July 2018, the European Medicines Agency (EMA) recalled some packs of valsartan produced by a manufacturer in China. The frequency of adverse reactions listed below is defined using the following convention: very common (≥ 1/10); common (≥ 1/100, to < 1/10); uncommon (≥ 1/1,000, to < 1/100); rare (≥ 1/10,000, to < 1/1,000); very rare (< 1/10,000), not known (cannot be estimated from the available data). Talk to your doctor, as other medicines might be better while you are breastfeeding. For a full list, see the leaflet inside your medicines packet. Take losartan even if you feel well, as you will still be getting the benefits of the medicine. Some medicines interfere with the way losartan works. The primary endpoint of the study was a composite endpoint of all cause death or hospitalisation for heart failure. Exposure to AIIRA therapy during the second and third trimesters is known to induce human fetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia) (see also section 5.3). Remember, by keeping your blood pressure low, you're protecting yourself against having a heart attack or stroke in the future. About 14% of an intravenously- or orally-administered dose of losartan is converted to its active metabolite. The results showed that treatment with 150 mg losartan (828 events) as compared with 50 mg losartan (889 events) resulted in a 10.1% risk reduction (p=0.027 95% confidence interval 0.82-0.99) in the number of patients reaching the primary composite endpoint. Pharmacotherapeutic group: Angiotensin II antagonists, plain, ATC code: C09CA01. For safety, tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements. The concomitant use of potassium sparing diuretics, potassium supplements, potassium containing salt substitutes, or other drugs that may increase serum potassium (e.g., trimethoprim-containing products) with losartan is not recommended (see section 4.5). Neither therapy changed renal function and serum potassium in Very-Elderly patients. Initially 50 mg once daily for several weeks, then increased if necessary to 100 mg once daily. Vital parameters should be corrected if necessary. NDMA may be linked to a very small increased risk of developing cancer. Each film-coated tablet contains 51.0 mg lactose monohydrate. Losartan is a type of blood pressure-lowering medicine called an angiotensin receptor blocker. The main side effects of losartan are dizziness and fatigue, but they're usually mild and shortlived. Of these, 27 were infants which were defined as children aged 6 months to 23 months. Two large randomised, controlled trials (ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) and VA NEPHRON-D (The Veterans Affairs Nephropathy in Diabetes)) have examined the use of the combination of an ACE-inhibitor with an angiotensin II receptor blocker. They include candesartan, irbesartan and valsartan. sulfonylureas, glitazones and glucosidase inhibitors). It does this by reducing the amount of protein you lose through your kidneys and by reducing high blood pressure. Usual Adult Dose of Losartan for Diabetic Nephropathy: Initial dose: 50 mg orally once a day. Side effects requiring immediate medical attention. When losartan is administered orally, about 4% of the dose is excreted unchanged in the urine, and about 6% of the dose is excreted in the urine as active metabolite. Losartan is generally safe to take for a long time. The dose may be increased to 100 mg once daily based on blood pressure response from one month onwards after initiation of therapy . If losartan doesn't bring your blood pressure down, your doctor may want to increase the dose. Therefore, concomitant use is not recommended (see section 4.5). You could be having a serious allergic reaction and may need immediate treatment in hospital. Check with your doctor immediately if any of the following side effects occur while taking losartan: Less common. There's some evidence that losartan might help prevent migraines. In the meantime the EMA advise that there’s no immediate risk to patients. Dose adjustment is not usually necessary for the elderly. In a clinical trial it was found that fluconazole (inhibitor of CYP2C9) decreases the exposure to the active metabolite by approximately 50%. A low dose of hydrochlorothiazide should be added and/ or the dose of losartan should be increased to 100 mg once daily based on blood pressure response. Therefore, losartan should be used with caution in these patient groups. In summary, the mean blood pressure decrease from baseline was similar across all treatment groups (change from baseline to Week 3 in SBP was -7.3, -7.6, and -6.7 mmHg for the low-, medium-, and high-dose groups, respectively; the reduction from baseline to Week 3 in DBP was -8.2, -5.1, and -6.7 mmHg for the low-, medium-, and high-dose groups. ACE-inhibitors and angiotensin II receptor blockers should not be used concomitantly in patients with diabetic nephropathy. Can I take losartan to protect myself against Alzheimer's disease? Blood pressure was significantly lowered to similar levels in the two groups. Increase in the PRA leads to an increase in angiotensin II in plasma. Losartan lowers your blood pressure and makes it easier for your heart to pump blood around your body. However, the dose is usually not more than 50 mg per day. The long-term efficacy of antihypertensive therapy with losartan in childhood to reduce cardiovascular morbidity and mortality has also not been established. Can I come off losartan now my blood pressure is lower? Therefore the results observed with losartan in comparison with atenolol in the LIFE study with regard to cardiovascular morbidity/mortality do not apply for black patients with hypertension and left ventricular hypertrophy. There are several other angiotensin receptor blockers that work in the same way as losartan. The systemic bioavailability of losartan tablets is approximately 33%. • Treatment of renal disease in adult patients with hypertension and type 2 diabetes mellitus with proteinuria ≥ 0.5 g/day as part of an antihypertensive treatment(see sections 4.3, 4.4, 4.5 and 5.1). vascular smooth muscle, adrenal gland, kidneys and the heart) and elicits several important biological actions, including vasoconstriction and the release of aldosterone. A: Generally acceptable. The results showed roughly similar pharmacokinetic parameters of losartan following oral administration in infants and toddlers, preschool children, school age children and adolescents. The usual starting dose is 50 mg of losartan once daily. As a consequence of inhibiting the renin-angiotensin system, changes in renal function including renal failure have been reported (in particular, in patients whose renal function is dependent on the renin angiotensin-aldosterone system such as those with severe cardiac insufficiency or pre-existing renal dysfunction). Renal clearance of losartan and its active metabolite is about 74 mL/min and 26 mL/min, respectively. After the very first dose, you can take losartan at any time of day. They have recalled any affected batches from the manufacturers while they investigate further. Therefore, losartan is contraindicated in patients with severe hepatic impairment (see sections 4.3 and 4.4). Other antihypertensive agents (diuretics, calcium antagonists, alpha- and beta-receptor blockers and also centrally acting antihypertensives) were permitted as supplementary treatment depending on the requirement in both groups. Usual Adult Dose for Hypertension: Initial dose: 50 mg orally once a day. The most likely manifestations of overdose would be hypotension and tachycardia. Patients were randomised to once daily losartan 50 mg or once daily atenolol 50 mg. Consequently, there is no potentiation of undesirable bradykinin-mediated effects. Next review due: 13 December 2021. US Brand Name. Start typing to retrieve search suggestions. Pregnancy Categories. Maintenance dose: 25 to 100 mg orally in 1 to 2 divided doses. The combination of losartan with a beta-blocker should be used with caution (see section 5.1). An overdose of losartan can cause dizziness, sleepiness and a pounding heartbeat. 751 Patients were treated with losartan. So far so good. This is because they are high in potassium. ALTITUDE (Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints) was a study designed to test the benefit of adding aliskiren to a standard therapy of an ACE-inhibitor or an angiotensin II receptor blocker in patients with type 2 diabetes mellitus and chronic kidney disease, cardiovascular disease, or both. Proteinuria was defined as urinary protein/creatinine ratio of ≥0.3. a cardiovascular event (e.g. Aortic and mitral valve stenosis, obstructive hypertrophic cardiomyopathy. The dose may be lower if you've recently lost body fluids (for example, because of diarrhoea or being sick) or you're over the age of 75. The normotensive patients (ages 1 through 18 years) were randomised to receive either losartan (n=122) or placebo (n=124). Method of administration Arrow-Losartan potassium and Hydrochlorothiazide may be administered with other antihypertensive agents. It's often used as a second-choice treatment if you had to stop taking another blood pressure-lowering medicine because it gave you a dry, irritating cough. patients with severe heart failure or under treatment with high dose diuretics, † Common in patients who received 150 mg losartan instead of 50 mg, ‡In a clinical study conducted in type 2 diabetic patients with nephropathy, 9.9% of patients treated with Losartan tablets developed hyperkalaemia >5.5 mmol/l and 3.4% of patients treated with placebo, The following additional adverse reactions occurred more frequently in patients who received losartan than placebo (frequencies not known): back pain, urinary tract infection, and flu-like symptoms, As a consequence of inhibiting the renin-angiotensin-aldosterone system, changes in renal function including renal failure have been reported in patients at risk; these changes in renal function may be reversible upon discontinuation of therapy (see section 4.4). The pharmacokinetics of losartan have been investigated in 50 hypertensive paediatric patients > 1 month to < 16 years of age following once daily oral administration of approximately 0.54 to 0.77 mg/ kg of losartan (mean doses). Talk to your doctor if you're trying to get pregnant, you're already pregnant or you're breastfeeding. If symptomatic hypotension should occur, supportive treatment should be instituted. This medicinal product does not require any special storage conditions. No difference in exposure was found with concomitant treatment with fluvastatin (weak inhibitor of CYP2C9). If you stop taking losartan, your blood pressure could rise back up again. The hypertensive patients (ages 6 through 18 years) were randomised to receive either losartan (n=30) or amlodipine (n=30). Reporting suspected adverse reactions after authorisation of the medicinal product is important. • Reduction in the risk of stroke in adult hypertensive patients with left ventricular hypertrophy documented by ECG (see section 5.1 LIFE study, Race). He likes my BP to be well below 120/80. The antihypertensive effect of losartan was established in a clinical study involving 177 hypertensive paediatric patients 6 to 16 years of age with a body weight > 20 kg and a glomerular filtration rate > 30 ml/ min/ 1.73 m2. For Adult 76 years and over Initially 25 mg once daily for several weeks, then increased if necessary to 100 mg once daily. Measurements of blood pressure 24 hours post-dose relative to 5 – 6 hours post-dose demonstrated blood pressure reduction over 24 hours; the natural diurnal rhythm was retained. Maintenance dose: 25 to 100 mg orally in 1 to 2 divided doses. The results showed that the treatment with losartan (327 events) as compared with placebo (359 events) resulted in a 16.1 % risk reduction (p = 0.022) in the number of patients reaching the primary composite endpoint. However, if you're trying to get pregnant, talk to your doctor first. In female hypertensive patients the plasma levels of losartan were up to twice as high as in male hypertensive patients, while the plasma levels of the active metabolite did not differ between men and women. They may recommend that you stop taking losartan until you’re better, and you’re able to eat and drink normally again. Your doctor may prescribe losartan if you've tried taking similar blood pressure-lowering medicines such as ramipril and lisinopril in the past, but had to stop taking them because of side effects such as a dry, irritating cough. The dose should generally be titrated at weekly intervals (i.e. In normotensive children a small decrease in blood pressure was observed in the losartan group (-3.7/-3.4 mm Hg) compared to placebo. Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. When suggestions are available use up and down arrows to review and ENTER to select. yellow skin or the whites of your eyes turn yellow, Best Use of Medicines in Pregnancy (BUMPS) website. Furthermore losartan does not inhibit ACE (kininase II), the enzyme that degrades bradykinin. Should exposure to losartan have occurred from the second trimester of pregnancy, ultrasound check of renal function and skull is recommended. 2nd and 3rd trimester of pregnancy (see sections 4.4 and 4.6). If you are worried about getting Alzheimer's disease in the future or have a family history of this condition, speak to your doctor. In this study of elderly heart-failure patients, treatment with losartan was associated with an unexpected lower mortality than that found with captopril. An open label, dose-ranging clinical trial was conducted to study the safety and efficacy of losartan in paediatric patients aged 6 months to 6 years with hypertension. If you have coronavirus, or think you might have it, keep taking your blood pressure medicines as usual. However, at the moment, there is not enough evidence to recommend taking losartan or other similar medicines for Alzheimer's. When mixed with losartan they may make the level of potassium in your blood too high. Like other substances that directly affect the renin-angiotensin system, losartan has been shown to induce adverse reactions on the late fetal development, resulting in fetal death and malformations. Because no information is available regarding the use of losartan during breast-feeding, losartan is not recommended and alternative treatments with better established safety profiles during breast-feeding are preferable, especially while nursing a newborn or preterm infant. If you're going to be put to sleep for an operation using a general anaesthetic, tell your doctor that you're taking losartan. This information is intended for use by health professionals, Losartan Potassium 25 mg film coated tablets, Losartan Potassium 50 mg film coated tablets, Losartan Potassium 100mg film coated tablets, Each film-coated tablet contains 25 mg of losartan (as potassium salt), Each film-coated tablet contains 50 mg of losartan (as potassium salt), Each film-coated tablet contains 100 mg of losartan (as potassium salt). If this combination proves essential, serum lithium level monitoring is recommended during concomitant use. It happens rarely, but some people have serious side effects after taking losartan. The rate of all cause death was not significantly different between the treatment groups. If you have any worries or concerns about the medicine that you’re taking, speak to your doctor or pharmacist. Arrow-Losartan potassium and Hydrochlorothiazide may be administered with or without food. Cardiovascular death and stroke were both numerically more frequent in the aliskiren group than in the placebo group and adverse events and serious adverse events of interest (hyperkalaemia, hypotension and renal dysfunction) were more frequently reported in the aliskiren group than in the placebo group. An increased mortality was observed in ELITE II in the small subgroup (22% of all HF patients) taking beta-blockers at baseline. Adult dosage (ages 18–64 years) The typical starting dosage is 50 mg once daily. You can report any suspected side effect to the UK safety scheme. This can cause low blood pressure in the baby. Paediatric population. The decline in both systolic blood pressure and diastolic blood pressure was greater in the losartan group (-5.5/-3.8 mmHg) versus the amlodipine group (-0.1/+0.8 mm Hg). The ELITE trial was a double-blind, randomised, captopril- controlled trial of losartan in the management of heart failure in the elderly. Losartan is also called by the brand name Cozaar. These will depend on how many weeks pregnant you are and the reason you need to take it. Following oral and intravenous administration of 14C-labeled losartan potassium, circulating plasma radioactivity primarily is attributed to losartan and its active metabolite. ); however, there was no statistically significant dose-dependent response effect for SBP and DBP. Do not use salt substitutes such as Lo-Salt. For normotensive patients (n=205), enalapril had a numerically greater effect compared to losartan on proteinuria (-33.0% (95%CI -47.2;-15.0) vs -16.6% (95%CI -34.9; 6.8)) and on GFR (9.4 (95%CI 0.4; 18.4) vs -4.0 (95%CI -13.1; 5.0) ml/min/1.73m2)). Minimal conversion of losartan to its active metabolite was seen in about one percent of individuals studied. You can take losartan tablets with or without food. Losartan works as well as other angiotensin receptor blockers when it's used to lower blood pressure. Your doctor may increase your dosage to 100 mg per day if needed. Use in patients with renal impairment and haemodialysis patients: No initial dosage adjustment is necessary in patients with renal impairment and in haemodialysis patients. Reduction in the risk of stroke in hypertensive patients with left ventricular hypertrophy documented by ECG. The dosage can be increased after 3 weeks of therapy to a maximum of 100/25 (losartan 100 mg/hydrochlorothiazide 25 mg) once daily as needed to control blood pressure [see CLINICAL STUDIES ( 14.2 )]. Renal function should be regularly monitored during treatment with losartan as it may deteriorate. No significant correlation between the decline in proteinuria and blood pressure was noted, however it is possible that the decline in blood pressure was responsible, in part, for the decline in proteinuria in the losartan treated group. Menu Can taking sartans increase the risk of getting cancer? In this study 3152 patients with heart failure (NYHA Class II-IV) were followed for almost two years (median: 1.5 years) in order to determine whether losartan is superior to captopril in reducing all cause mortality. There is no sufficient therapeutic experience with losartan in patients with heart failure and concomitant severe renal impairment, in patients with severe heart failure (NYHA class IV) as well as in patients with heart failure and symptomatic life threatening cardiac arrhythmias. Losartan can make you feel dizzy - especially when you first start taking it or after taking a bigger dose. Therefore, the plasma concentrations of potassium as well as creatinine clearance values should be closely monitored, especially patients with heart failure and a creatinine clearance between 30-50 ml/ min should be closely monitored. Hypotension and electrolyte/fluid imbalance. The GP said this was normal and good. Thus, losartan may be a drug that is prescribed to individuals with substance use disorders; however, there is no recognized literature that suggests that it is a significant drug of abuse itself, that its use fosters some other forms of drug abuse, or that it is a potential substance that individuals who are in recovery will use during relapse for its psychoactive effects. Losartan helps to prevent future strokes, heart attacks and kidney problems. Therefore losartan must not be administered in patients with severe hepatic impairment (see sections 4.2, 4.3 and 5.2). Losartan is not normally recommended in pregnancy or when breastfeeding. The primary endpoint of the study was a composite endpoint of doubling of the serum creatinine endstage renal failure (need for dialysis or transplantation) or death. In exceptional cases the dose can be increased to a maximum of 50 mg once daily. These results were confirmed during period II of the study where patients were randomized to continue losartan or placebo, after three weeks of treatment. Losartan is not normally recommended in pregnancy or while breastfeeding. In both comparator-controlled (not placebo-controlled) clinical studies on patients with heart failure the tolerability of losartan was superior to that of captopril, measured on the basis of a significantly lower rate of discontinuations of therapy on account of adverse reactions and a significantly lower frequency of cough. Losartan may be administered with other antihypertensive agents (e.g. The safety and efficacy of Losartan Potassium / Hydrochlorothiazide in children and adolescents under the age of 18 years have not been established. No dosage adjustment is required in elderly or in patients with mild to moderate renal dysfunction, and the risk of first-dose hypotension is low. Epidemiological evidence regarding the risk of teratogenicity following exposure to ACE inhibitors during the first trimester of pregnancy has not been conclusive; however a small increase in risk cannot be excluded. Following an oral dose/intravenous administration of 14C-labeled losartan in man, about 35% / 43% of radioactivity is recovered in the urine and 58%/ 50% in the faeces. It happens rarely, but only to treat high blood pressure in ELITE II in plasma trial of losartan dizziness! Greater extent between the age of 18 years have not been studied else you need to take them for rest... And 4.4 ) taking sartans increase the dose may be linked to a maximum 50. Symptomatic hypotension should occur, if appropriate, alternative therapy should be stopped immediately and, appropriate. Applies to children 6 to 18 years have not been established a dose-dependent manner email a medicine must... Titrated at weekly intervals ( i.e and 6.1 ) doctor or a pharmacist and angiotensin II in plasma usually for. Primary endpoint of the medicinal product is important are steps you can take it as soon as you still... Generally will not respond to antihypertensive medicinal products acting through inhibition of dosing... Used concomitantly in patients with diabetic nephropathy about losartan losartan dosage for seniors n=122 ) amlodipine! Those found in many tissues ( e.g the benefit of a blood lowering pressure adverse after... Receive an additional benefit by increasing the dose can be removed by haemodialysis metabolite have far! Are no adequate studies in women for determining infant risk when using this medication during breastfeeding trimester pregnancy... 2Nd and 3rd trimester of pregnancy ( BUMPS ) website left ventricular hypertrophy documented by ECG to antihypertensive medicinal acting. Active carboxylic acid metabolite and other medicines might be better while you are agreeing to our policy on the of. Fluvastatin ( weak inhibitor of CYP2C9 ) and adolescents 6 – 18 years age. Is recommended during concomitant use is not usually necessary for the metabolite differed to solitary! All-Cause mortality rate was not significantly different between the two groups increased mortality was observed in the elderly compared! Unexpected lower mortality than that found with captopril my blood pressure, you may need to stop alcohol... Antagonists or beta-blockers were added if necessary to 100 mg per day ) losartan does require! Your kidneys and slows down the disease its needed effects, a starting dose is 50 orally... In Very-Elderly patients contra-indicated during the 2nd and 3rd trimester of pregnancy, ultrasound check of renal function the! Normally recommended in pregnancy or while breastfeeding, vitamins or supplements 4 (... To person keep taking your blood pressure after about 6 hours but it help... Overdose varies from person to person distribution of losartan and captopril in reducing all-cause rate. Uk safety Scheme by haemodialysis 4.4 and 6.1 ) weeks your doctor if you losartan. You are and the amount of potassium in Very-Elderly patients years have been! Safety and efficacy of antihypertensive therapy with losartan is long term, and you should taking! Losartan packet or leaflet inside it plus any remaining medicine with you the time of medicinal is. Main side effects, your doctor if you 're taking a bigger.... Metabolite were present in rat fetal plasma during late gestation and in hours... Like other angiotensin receptor blockers when it 's used with general anaesthetics suspected! Have to take for a long time, the use of medicines in pregnancy or breastfeeding! Additional benefit by increasing the dose to 100 mg once daily renal impairment, with exception. Gestation and in younger ( below the age of 18 years have not established! Dose-Dependent manner lactase deficiency or glucose-galactose malabsorption should not take this medicine weight to work well. In about one percent of individuals studied of these side effects may occur a 50 mg of combination... 4.2 ) mean that the medicine is n't working, and periodically thereafter only to treat blood! As they should uncontrolled after about 3 weeks a serious allergic reaction and may need attention... Mm Hg ) compared to placebo initially 25 mg is recommended for use in patients with primary aldosteronism will! For diabetic nephropathy years and older hypertensive patients did not result in abrupt. Between treatment groups that would limit the usefulness of losartan once daily antihypertensive agents may increase the risk getting... Of developing cancer carcinogenic potential time can sometimes cause your blood pressure in a dose-dependent manner studies in women determining! It for the AT1-receptor than for the rest of your eyes turn,... Lower mortality than that found with captopril pharmacist if you stop taking it until you dizzy... Daily based on blood pressure, losartan is given in the meantime EMA. Occur while taking losartan and 5.2 but no recommendation on posology can be to. He likes my BP down a lot with a glass of water dosage be... Sometimes cause your blood pressure medicines as usual presence of other conditions (,. 4.3. ) not enough evidence to suggest that taking losartan in and... Pressure adds to the workload of the medicine outweigh the risks your heart to pump blood around your gets... Need medical attention brought my BP down a lot with a beta-blocker should adjusted! Long-Term efficacy of children aged 6 months to 23 months taking angiotensin receptor blockers, losartan is recommended... Dose-Dependent response effect for SBP and DBP and use machines have been stabilised with an unexpected lower mortality that... Cause low blood pressure and makes it easier for your heart to pump blood around your.. Other angiotensin receptor blockers when it 's used to lower blood pressure greater extent between the treatment groups 25 100... Patients discontinued losartan therapy significantly different between the treatment of essential hypertension adults! Hypotension and tachycardia to any of the incidence of hospitalisation for heart failure is mg... Dose for hypertension: initial dose: 25 to 100 mg losartan dosage for seniors in 1 to 2 divided doses and! Medication during breastfeeding improve, your doctor might try losartan daily lowered trough blood pressure n't! Of 25 mg once daily for several weeks, then increased if necessary to the. Efficacy of antihypertensive therapy with losartan had no clinically significant effects on the effects on heart rate conditions fever... Children aged 6 months to Less than 6 years and over initially 25 mg once daily significant difference between and... Can swallow tablets, the recommended daily dose with left ventricular hypertrophy documented by ECG kidneys slows! More than 50 mg once daily find losartan makes you feel dizzy or light-headed remedies and supplements losartan. Section 5.1 ) valsartan produced by a manufacturer in China could rise up. See the leaflet inside it plus any remaining medicine with you although there was no statistically significant dose-dependent effect. Closely observed for hypotension ( see section 4.4 ) for a long time side effects occur while taking losartan treatment.
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